Authentic product results through flexible mass spectrometry and HPLC instrumentation.
Focus BioLabs offers analytical testing for a wide range of chemical research compounds, including peptides and small molecules. By using HPLC with UV detection combined with mass spectrometry, we can confirm the compounds you are manufacturing or importing are correctly identified and meet your specifications.
Our mass spectrometry instrumentation includes multiple Bruker QTOFs for accurate mass measurements and a Thermo Scientific Velos Pro ion trap for highly sensitive analyte detection in complex matrices. We use Waters Acquity UPLC series HPLCs for chromatographic analyses exclusively because of the reliability and reproducibility Waters is known for in the pharmaceutical industry.
Linear ion traps are low-resolution mass spectrometers with high sensitivity and fast scan rates. They are ideal for monitoring low-abundance analytes in complex background matrices such as serum and plasma.
Focus BioLabs has a Thermo Scientific LTQ Velos Pro linear ion trap mass spectrometer paired with a Waters nanoAcquity HPLC. Detection levels down to 5 pg/ml are frequently achieved using this instrument combination, making it ideal for pharmacokinetic studies. This instrumentation is operated under Good Laboratory Practice, ensuring the utmost reliability of the data generated.
QTOF (quadrupole time of flight) mass spectrometers are medium-to high-resolution instruments used to accurately measure the molecular weight of small molecules and proteins.
Focus BioLabs has three Bruker Compact QTOF mass spectrometers for accurate measurement of small molecules and peptides with a resolution of 20,000, or around two decimal places. This higher degree of mass accuracy allows for confident compound identification and formula determination.
High-performance liquid chromatography (HPLC) is used to separate compounds in a mixture before mass spectrometry analysis. We exclusively use Waters Acquity UPLC systems for their industry-leading reliability and reproducibility.
We utilize both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources to accommodate a wide range of compound polarities and types, ensuring optimal ionization for your specific analytes.
Our team can help you determine the best approach for your specific testing needs.
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